anticoagulants

ABSTRACTThromboembolic disorders affecting millions of people worldwide. Presently available anticoagulants are closely related to antiplatelet drugs and thrombolytic drugs by manipulating the various pathways of blood coagulation but having limited use due serious side effects. A medicinal herb Datura metel belongs to family Solanaceae, has been widely used in traditional medicine. In the present study, different concentrations (20-100 µg/ml) of aqueous extract of leaves of Datura metel was evaluated for in-vitro anticoagulant and clot lysis activity. The results showed that, there was concentration dependent increase in anticoagulant activity as a measure of increased prothrombin time activity. Similarly, there was concentration dependent increase in percentage clot lysis activity. A maximum 23.81% clot lysis activity was reported at concentration 100 µg/ml of extract. Thus, it was concluded that, aqueous extract of leaves of Datura metel has potential in-vitro anticoagulant and clot lysis activity and may be beneficial in the treatment of cardiovascular diseases. Keywords: Clot lysis, cardiovascular diseases, prothrombin time, anticoagulants, 

Hemorrhagic ovarian cysts usually result from haemorrhage into a corpus luteum or other functional cysts. It is a frequent and potentially life threatening complication in women on chronic anticoagulation therapy. Surgical management has been a traditional approach in managing hemorrhagic ovarian cyst. However conservative management is now dominating the trend in carefully selected patients .For prevention of recurrence of ovulation related bleeding it is mandatory to use a ovulation suppressing agent during the monthly  follow up. Here we present two case reports who had been receiving oral anticoagulants – Vit K antagonist for prosthetic heart valves and are treated as a result of ruptured corpus luteal cyst. One was treated surgically other was treated conservatively. They were discharged with advise of DMPA for ovulation suppression in the follow up. Even though VKA’S are cost effective and efficacious in preventing valve thrombus, because of life threatening hemorrhage and periodic INR monitoring necessitate the need for researches to find an safe and effective alternative newer oral anticoagulants for women in reproductive age group.