corticosteroids

ABSTRACTImmune thrombocytopenia (ITP) is a diverse condition in which managing and predicting patient responses to therapy poses a problem. It can develop in healthy people, including kids and young adults, after a viral infection and significantly impair a patient's quality of life. Thrombopoietin receptor agonists (TPO-RAs), spleen tyrosine kinase (Syk) inhibitors, or immunological suppression (corticosteroids and intravenous immunoglobulins) are the mainstays of ITP treatment. This article provides a quick overview of the occurrence, aetiology, classification, and several therapy approaches based on recent research. We also present a case report on ITP and summarize the key points in the diagnosis and management of it. In order to improve the disease prognosis and lower the incidence or frequency of refractoriness, a deeper understanding of ITP is needed in order to offer patients with individualized therapy alternatives. Keywords: Immune thrombocytopenia, Thrombopoietin receptor agonists, corticosteroids, Syk inhibitors, immunoglobulins.

ABSTRACTSelection of glucocorticoids along with its dose and duration are the important aspects which should be considered while prescribing to the critically ill hospitalized patients. The purpose of this study was to assess the prescription pattern of glucocorticoids and promote appropriate use of it. A prospective observational study, conducted for a period of six months from September 2019 to February 2020 in Navodaya Medical College, Hospital & Research Centre (NMCH&RC) Raichur. Current study was performed in patients of age 18 or above and either sex who were prescribed with Glucocorticoid. All the new cases with drug prescription were included in the study.  Patients who were below 18, ICU patient, lactating and pregnant women were excluded from the study. All the collected data were analyzed with the help of standard guidelines. In the present study, the prescribing of glucocorticoids is found to be appropriate about 84.40 %. However, to ensure safe, effective and well-balanced therapeutic management with glucocorticoids, both patients and prescribers should be more aware of the appropriate dose, dosage regimen, route of administration, duration of therapy and overall guidelines for glucocorticoids prescribing. Hence the involvement of clinical pharmacists in clinical practice helps to increase proper usage of glucocorticoids and optimum outcome. Our study concludes that standard treatment guidelines should be developed at hospital for prescribing of glucocorticoids taking into consideration the patient specific parameters which will improve therapeutic outcomes. Keywords: Prescribing pattern, glucocorticoids, corticosteroids, appropriateness, inappropriateness.