nanoparticles

ABSTRACTNanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and  DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics. Keywords: biodegradable chitosan, nanoparticles, almotriptan malate,  mucoadhesion  

Silver nanoparticles inhibit microbial growth and have been gaining importance as a solution for numerous biomedical applications. In this study, synthesis of silver nanoparticles is carried out using Bacillus species isolated from silver fabrication area. Nanoparticle Tracking Analysis and Scanning Electron Microscopy revealed the size of particles ranged from 39 to 67.4 nm and spherical shape. XRD spectra revealed nanoparticles are of silver oxide. The anti-bacterial activity of silver oxide nanoparticles of Bacillus species was prominent against the three clinical strains of major Urinary Tract Infection (UTI) causing Escherichia coli, Staphylococcus aureus and Pseudomonas aeruginosa.