polyphenols

ABSTRACTSARSCoV2 infection has caused and will continue to cause considerable human suffering. Research on the pathogenesis of viruses has yielded consistent results from various tests of virus entry and spread to the host. These studies also revealed a strong association between harmless inflammations, aging and metabolic disorders, and SARSCoV2 infection and its prognosis. Diet helps regulate inflammation, and nutritious foods can inhibit the entry of viruses. Therefore, we have compiled the literature on antiviral health products that are effective against other similar coronaviruses. The purpose of this study is to comprehensively review the available information about the antiviral activity of nutritious foods and discuss the impact of these findings on the design of diets that can enhance innate immunity and prevent COVID19. This review emphasizes the fundamental impact of nutritious food and diet on inhibiting virus entry, and provides a new perspective for the prevention and treatment of COVID19. Keywords: SARSCoV2, diet, plant protease inhibitors, polyphenols, biologically active peptides

ABSTRACTWith increasing incidences of side effects and adverse drug reactions, the consumer choices are more inclining towards natural products and medicines obtained from natural sources. One such emerging class of products are 'Nutraceuticals'. Nutraceutical is a compound defined as food or parts of a food having health benefits and helps in prevention and treatment of diseases. It includes isolated nutrients, dietary supplements, herbal products and processed foods. Nowadays Nutraceuticals are preferred for providing additional health benefits and for prevention and treatment of diseases due to its safety, potential and therapeutic efficacy. Nutraceuticals have advantage over the drugs or medicines because they are naturally found dietary supplements and don’t have side effects .These are classified into three categories which are Nutrients , Herbals and Dietary supplements .Nowadays, sedentary and passive lifestyles have become common causes of many diseases related to lifestyle, metabolism, weight-related disorders, cardiovascular disorders etc. The incidence of cardio-vascular diseases have been increasing since decades throughout the world. Studies show that India is the highest contributor to the number of cases of cardiovascular diseases. Cardio Vascular Diseases (CVD) are the most common health problem faced by the populations it may be fatal at later stages. Recent studies have shown that cardiovascular risk factors like obesity, diabetes, hypertension are highly prevalent even in younger generations. Various Nutraceuticals are used for the prevention and treatment of CVD or to reduce the risk factors which leads to CVD , these risk factors are Atherosclerosis, Dyslipidemia , Hypertension , Diabetes Mellitus . Commonly known Nutraceuticals used to treat CVD or reducing its risk factors are Berberine , ?-glucans , Polyphenols , Plant sterols or stanols and these are widely found in plants , foods and food products from plant origin , vegetables , cereals ,

Citrus sinensis has intensively been used for its nutritional and therapeutic values, usually attributed to their antioxidant properties. Several studies have earlier focused on its fruits, seeds, oils, juice and flowers. This study focuses on leaves and aimed at determining radical scavenging capacity (RSC), antiradical power(ARP), total polyphenols (TPC) and flavonoids (TFC) content of the aqueous (AE), hydroethanolic (HEE) and ethanolic (EE) extracts and their activities on free radicals DPPH•, ABTS+ and NO. Phenolic compounds of all the extracts were measured by Folin-Ciocalteu assays. RSC of 1,1-diphenyl-2-picrylhydrazyl (DPPH•), 2,2’-azinobis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS+) and nitric oxide (NO•) radicals were measured. Also, the reducing power of extracts on phosphomolybdenum was evaluated by total antioxidant capacity (TAC) assay, antiradical power and EC50 were determined. All the extracts possessed high TPC ranging from 306.67 ± 43.72 to 353.33 ± 30.55 µg of Eq Catechin /mg respectively for EA and EE.  EE, EA, EC showed their ability to scavenge all the radicals and an important reducing power. Aqueous extracts presented the lower EC50 (mg/ml) 4.60, 4.27, and 4.01x10-4 with DPPH•, ABTS+, NO• respectively and the highest ARP. Many correlations observed between TAC and ABTS+-RSC (r = 0.958, p