C. Narasimha Rao

ABSTRACTGround water quality and its impact on human health in an industrial area near Tirupati, India has been assessed. Water samples were collected from 40 different locations of Vadamala Pet near Tirupati and analyzed for physicochemical parameters such as pH, electrical conductivity, total dissolved solids, total hardness, calcium, chlorides, sulphates, nitrates and dissolved oxygen etc. The found values of physicochemical parameters were compared with the World Health Organization (WHO) water quality standards. Based on the physico-chemical analysis and correlation studies, it was found that ground water of some of the studied areas was polluted and not suitable for drinking purpose. Thus the ground water of such areas needs purification before drinking. Keywords: Ground water, physicochemical parameters, purification, total dissolved solids, hardness.

ABSTRACTThe impact of drinking water quality at different locations of Ramapuram, near Tirupati, India has been assessed to study its effects on human health. Water samples were collected from different locations and analyzed for physicochemical parameters such as pH, hardness, alkalinity, calcium, magnesium, iron, nitrates, chlorides, sulphates, electrical conductivity, total solids (TS), total dissolved solids (TDS), total suspended solids (TSS), dissolved oxygen (DO), chemical oxygen demand (COD) and bio chemical oxygen demand (BOD). The results were compared with the World Health Organization (WHO) water quality standards. Correlation studies reveal that drinking water of some of the areas was not suitable for drinking purpose and needs purification before drinking. Keywords: Water quality, Human health, BOD, TSS, TDS, Correlation coefficient.

ABSTRACTA simple, sensitive and rapid spectrophotometric method has been developed for the estimation of Amphetamine (AM) in bulk and in pharmaceutical formulations using 2,3-dichloro-5,6-dicyano-p-benzoquinone (DDQ). The proposed method is based on the formation of charge-transfer complex between AM and DDQ. AM in the presence of DDQ formed pale wine red color complex which showed a maximum absorbance at 465 nm against the blank. The limit of detection and quantitation were 0.1395 mg/ml and 0.4644 mg/ml respectively. The results of analysis were validated by recovery studies, accuracy, precision, LOD, LOQ, robustness and ruggedness, which indicated that the present method can be successfully applied for the determination of AM in pure and in pharmaceutical formulations. Keywords: Spectrophotometric method, Amphetamine, Charge-transfer complex, DDQ.

ABSTRACTA simple and sensitive spectrophotometric method has been developed for the determination of procainamide (PA) in pure and pharmaceutical formulations. The proposed method is based on the formation of charge-transfer complex between the drug and 1-chloro-2, 4-dinitrobenzene (CDNB). PA in the presence of CDNB formed yellowish red colored complex, which showed a maximum absorbance at 410 nm. The limit of detection and quantitation were 0.1183 mg/ml and 0.3940 mg/ml respectively. The influence of commonly used excipients on the determination of PA was studied. Keywords: Spectrophotometric method, Procainamide, CDNB, Charge-transfer complex.