Nimmy N John

ABSTRACTDiabetes mellitus is a metabolic-cum-vascular disorder of numerous etiologies described by constant hyperglycemia with aggravations of sugar, fat and protein digestion coming about deformities in insulin emission, insulin activity or both. This issue is every now and again connected with long haul harm, which can prompt disappointment of organs like eyes, kidney, nerves, heart and veins.. In India, diabetes mellitus is influencing 33% of the grown-up populace. It is basically connected with wellbeing trouble just as high financial weight at individual and populace levels. A forthcoming observational investigation was completed in-patients confessed to general medication division of NMCH&RC determined to have diabetes mellitus endorsed with combination treatment of Metformin + Glimepiride and combination treatment of Metformin + Teneligliptin from September 2019 to February 2020. Information was gathered from case sheets of patients and evaluated for their monetary weight dependent on the expense per tablet for long term. Cost viability proportion for the patients with controlled blood glucose level by utilizing a specific medication was determined and likelihood to lessen the diabetes mellitus was assessed. Among 70 in-patients, 38 patients (54.29%) were males and 32 patients (45.71%) were females. Patients are between the age gathering of 41-60 years were more (48.57%). Majority of the patients were conceded with known history of diabetes mellitus (81.43%). A large portion of the patients were endorsed with combination treatment of Metformin + Glimepiride (81.42%) followed with Metformin + Teneligliptin (18.57%). There was a critical positive connection (i.e., p value= 0.5607) between perseverance examples of patients with drug treatment. Likelihood of patients taking combination treatment of Metformin + Glimepiride was 77.19% trailed by patients with combination treatment of Metformin + Teneligliptin. Combination treatment of Metformin + Glimepiride are ha

ABSTRACTAntibiotic resistance is a condition where in the antibiotic loses its ability to efficiently control or kill the growth of the bacteria due to which the microorganism  continue to multiply  and grow in spite  of the drug being present in therapeutic levels in the body.  Some resistance have no human control over them. How ever, the current scenario of higher levels of antibiotic resistant bacteria are due to the excessive irrational use or abuse of antibiotics.  Patients who were prescribed with either piperacillin / tazobactum or a broad spectrum cephalosporin are enrolled in the study. Demographic data, co morbidities and antimicrobial exposures were collected from the patients. culture sensitivity of  Piperacillin/tazobactum was conducted in the department of microbiology. Resistance is a worldwide concern, it’s first and foremost problem encountering in antimicrobial therapy. In reality, the extensive use of ? lactam antibiotics in hospitals and communities has created major evolutionary pressures in bacteria to evolve towards resistance. The ? lactamase antibiotics are the largest and currently most widely used antibacterial agents. Therefore, their resistance means a level of antimicrobial activity associated with a high likelihood of therapeutic failure. The present study reveals the effectiveness of piperacillin/tazobactum over the commonly prescribed cephalosporins.Keywords: Antibiotic Resistance, cephalosporins, piperacillin, tazobactum, hepato biliary, ? lactamase