Treatment

ABSTRACTTo increase the success in Covid 19 treatment, many drug suggestions are presented, and some clinical studies to are shared in the literature. There have been some attempts to use some of these drugs in combination. However, using more than one drug together may cause serious side effects on patients. Therefore, detecting drug-drug interactions of the drugs used will be of great importance in the treatment of Covid 19. In this study, the interactions of 8 drugs used for Covid 19 treatment with 645 different drugs and possible side effects estimates have been produced using Graph Convolutional Networks. As a result of the experiments, it has been found that the hematopoietic system and the cardiovascular system are exposed to more side effects than other organs. Among the focused drugs, Heparin and Atazanavir appear to cause more adverse reactions than other drugs. In addition, as it is known that some of these 8 drugs are used together in Covid-19 treatment, the side effects caused by using these drugs together are shared. With the experimental result obtained, it is aimed to facilitate the selection of the drugs and increase the success of Covid 19 treatment according to the targeted patient. In this review, we conclude some AEs of vitamin-D, zinc, Remdesivir, Hydroxychloroquine or chloroquine, azithromycin, dexamethasone, amantadine, aspirin reported in different papers and we continue the rest of the drugs in second part of our review article. Keywords: Mechanism, Treatment, Side effects of covid -19 drugs

ABSTRACTAlzheimer's disease is one of the most devastating brain disorders of elderly humans. It is a decade has witnessed a steadily increasing effort directed at discovering the etiology of the disease and developing pharmacological treatment. Recent developments include improved clinical diagnostic guidelines and improved treatment of both cognitive disturbance and behavioral problems. Symptomatic treatment mainly focusing on cholinergic therapy has been clinically evaluated by randomized, double-blind, placebo-controlled, parallel-group studies measuring performance-based tests of cognitive function, activities of daily living, and behavior. The role of estrogen replacement, anti-inflammatory agents, and antioxidants is controversial and needs further study. Antidepressants, antipsychotics, mood stabilizers, anxiolytics, and hypnotics are used for the treatment of behavioral disturbance. Future directions in the research and treatment of patients with Alzheimer's disease include: applying functional brain imaging techniques in early diagnosis and evaluation of treatment efficacy; development of new classes of medications working on different neurotransmitter systems (cholinergic, glutamatergic, etc.) Keywords: Dementia, Symptoms and Stages of disease, Etiology, Pathology, Neurophysiology, Risk factors, Causes, Diagnosis, Treatment, Prevalence, 

Asthma creates a substantial burden on individuals and families as it is more often under-diagnosed and under-treated. India has an estimated 15-20 million asthmatics. Recognizing the signs and symptoms of asthma is important so that treatment and other interventions can begin early. Prospective observational study was conducted in the department of general medicine, RIMS, Kadapa for the period of 6 months aimed to assess the prevalence, risk factors and treatment in asthmatic patients. Patients were enrolled into the study on the basis of inclusion and exclusion criteria. A total of 122 asthma diagnosed patients were recruited under the inclusion criteria. Our study establishes that the prevalence of bronchial asthma was more in males 79 (64.75%) than in females 43 (35.25 %). The prevalence rate of our study was 20.71 %. Our study found that most patients (35.25%) are using multiple drug therapy, followed by triple combination therapy (33.61%). Our study concluded that the asthma has low incidence and prevalence rate among the total respiratory diseases patients admitted in the hospital with the most predominant risk factors as dust, smoke and climate variation. Most patients have used multiple drug therapy for treatment due to severity of disease.