lipid profile

Diabetic Milletus(DM).is the most frequent endogenous cause of fat metabolism- disorder. Therefore, the study aims to monitor the lipid profile  in  DM type 2 patients controlled and uncontrolled in Sana’a , Yemen. The study included 150 subjects from major public hospitals in Sana'a city, Yemen. 50 were diagnosed with DM type 2 controlled as group I and 50 were diagnosed with DM type 2 uncontrolled as group II. 50 subjects were healthy volunteers as control group. The biochemical parameters namely Fasting Blood Sugar (FBG) , and Glycelated Hemoglobin (HBA1c) were assayed in three groups. Data obtained were analyzed using suitable statistical tools. The lipid profile namely total cholesterol  mg/dl , triglyceride mg/dl HDL mg/dl, and LDL mg/ were assayed in DM type 2   controlled and uncontrolled and compared with control healthy group. The results were  described namely (166 ± 31 mg/dl ; 196 ± 50 ; 131 ± 28 ) , (146± 60 mg/dl ; 193 ± 94 ; 92 ± 30 ) , (37± 8.2 mg/dl , 36 ± 14, 42 ± 12 ), and (80 ± 25 mg/dl , 95 ± 30 , 76 ± 25) respectively.   According to above results , non different significant (p > 0.05) in all parameters of lipid profile was observed between DM  type 2  controlled and uncontrolled groups . while the results were observed different significant (p < 0.05) in serum levels of total cholesterol , triglyceride and LDL between controlled and healthy group and also non - different significant (p > 0.05) in serum levels of HDL between both . In addition, different significant (p > 0.05) in all parameters of lipid profile was observed between uncontrolled and control healthy groups .The study outcome concluded  that the hyperlipidemia may progressive in DM type 2 patients uncontrolled.

This work was carried out to investigate the lipid profile level in ethyl acetate extract of Ganoderma lucidum and atorvastatin in normal and alloxan induced diabetic mice.  Ganoderma lucidum and atorvastatin have shown to reduce LDL level 10.4 and 14.59%, TC level 06.76 and 09.78%, TG level 07.40 and 09.82% alongside equipotently increased HDL level to 09.33 and 15.18% respectively in normal mice. However, in case of diabetic mice, these values were 11.61 and 14.46% for LDL, 10.56 and 13.00% for TC, 10.38 and 13.96% for TG, 14.94 and 20.02% for HDL as well. Therefore, these results suggested that, intra peritoneal administration of Ganoderma lucidum have significantly (p