Uttar Pradesh

ABSTRACTIntussusception is quite common in the gastrointestinal tract and that too in the paediatric population though the aetiology is mostly idiopathic (90%). While in adults it is rare and is usually caused by an identifiable underlying lesion mainly neoplasm (70-90%) which usually acts as a lead point. It has a non-specific clinical presentation with a limited role of history and examination in the final diagnosis and Computed tomography is considered the gold standard investigation in establishing the diagnosis. We present an unusual case of jejuno-jejunal intussusception which was caused by a leiomyoma polyp. Thus an Exploratory laparotomy was done, resecting the polyp with the jejunal segment and the diagnosis was confirmed by histopathological examination. Keywords: Intussusception, Jejunal, Leiomyoma, Histopathology

ABSTRACTA series of N-{[2-(substituted methylidene)hydrazinyl](methylsulfanyl)methyl}-2-substituted-1,3-thiazolidine-4-carboxamide derivative were synthesized. The synthesized compounds were characterized by IR, NMR, Mass spectral data. The synthesized compounds were screened for their antifungal and antibacterial activity against pathogenic fungus and bacteria. Compounds TS-2, TS-4 and TS-9 exhibited good antibacterial and antifungal activity against the tested microorganisms, and the  rest of the molecules  shows good to moderate activity. Keywords: substitute thiazolidine, microwave assisted synthesis, minimum inhibitory concentration, antibacterial, antifungal.

The study was aimed to evaluate the release modifying potential of mucilage extracted from the Artocarpus heterophyllus in the formulation of oral sustained release tablets of diclofenac sodium. Preformulation studies performed on isolated mucilage involved the determination of physicochemical properties as well as flow properties of the mucilage. Compatibility studies including FTIR spectral analysis and drug-excipients compatibility studies showed no signs of incompatibility between drug, isolated gums or mucilage’s and other excipients. Diclofenac sodium matrix tablet formulations were prepared by wet granulation method using different drug: mucilage ratios viz. 1:0.25, 1:0.5, 1:1 and 1:2. The prepared formulations were evaluated for pre-compression parameters like angle of repose, bulk density, tapped density, hausner’s index and carr’s index for granules while tablets were evaluated for various post-compression parameters like tablet thickness, hardness, weight variation, friability, content uniformity, disintegration time, swelling behaviour and in-vitro drug release study. Among all the formulations, AH-3 and AH-4 showed a slow and complete drug release of 99.21% and 98.16%, respectively, over the period of 12 hrs and thereby exhibited satisfactory sustained drug release phenomenon. All the formulations follow zero order kinetics indicating that the drug diffuses at a comparatively slower rate. Finally, it was concluded that, Artocarpus heterophyllus mucilage can be used as drug release modifier in a particular concentration range and serve as a good binding agent in formulating oral sustained release matrix tablets.

Some novel 4-(aryliidineamino)-5-(1-(4-isobutylphenyl) ethyl)-4-yl-4H-1,2,4-triazole-3-thiols were prepared from the  reaction of carbon-di-sulphide and hydrazine hydrate in water to produce thiocarbohydrazides. The thiocarbohydrazides is then refluxed with ibuprofen for 2 hour, followed by cooling to room temperature and washing with sodium bicarbonate solution to produce  5-(1-(4-isobutylphenyl) ethyl)-4H-1,2,4- triazole-3-thiole. It is then refluxed with different aldehydes in the presence of ethanol and HCl to produce the title compounds. The synthesized compounds are recrystallized from ethanol and are analyzed for their physical and spectral data. They are screened for their anti-microbial activity and it was found that the title compounds are found to have moderate to good antimicrobial activity.