Monika

ABSTRACTThe oral dissolving tablets is defined as one, which has drug in it and when placed on tongue dissolves completely within a limited span of time, without additional requirement of water. Drug is released, dispersed in the saliva and swallowed and subsequently absorbed in the gastrointestinal tract (GIT). To achieve quick disintegration in oral solid dosage forms, it’s important to have high porosity in the tablets. This allows faster penetration of water and thus accelerates the disintegration. Oral dissolving tablets are the preferred means for patients with oral disorders and patients with dysphagia. It could also be friendly, with geriatric, paediatric and mentally challenged people. Oral dissolving tablet formulation are made by many techniques but in this study, we have made BARETab® ODT quick dissolving matrix using spray drier, characterized by Fourier-transform infrared spectroscopy and melting point test, morphology studied by scanning electron microscope, evaluation done with physicochemical test such as bulk density, flowability, average particle size distribution, compressibility index, water content and residue on ignition. Ondansetron oral dissolving tablet was thereafter made using with BARETab® ODT quick dissolving matrix. Ondansetron oral dissolving tablet was evaluated by in-vitro testing such as physical evaluation, weight uniformity, hardness, friability, disintegration and drug released profile. BARETab® ODT quick dissolving matrix have very good morphology, every particle contains binder, filler, glidant, sweetener and super disintegrant. It has outstanding physiochemical properties which helped to deliver good quality Ondansetron tablet. It has less friability, satisfactory hardness and quick disintegration time. Keywords: Orally Disintegrating Tablets, Fourier-transform infrared spectroscopy, melting point, Scanning electron microscope, In-Vitro Disintegration Time

Acne is one of the most common disorders that dermatologists and other health care providers treat. Although it most often affects adolescents, it is not uncommon in adults and can also be seen in children.Acne is a tenacious incendiary human skin syndrome, mainly defined at particular areas of skin characterized by microcomedones, comedones, nodules, pustules, itchiness, as well as invasive scar mainly on different parts of the body. Acne is a chronic inflammatory disorder of pilosebaceous unit that occurs for chronic periodas a result of increased sebum production induced by androgen, altered keratinisation, inflammation, and bacterial colonisation of hair follicles on the face, neck, chest, and back by Propionibacterium acnes. Different nano-advancement techniques like vesicular, colloidal drug delivery system have been discussed. These systems can be useful in scheming a novel delivery with low dose treatment for the cure of acne vulgaris. The current review focused on the better nanotechnological system that can be used in future for better and effective treatment of acne.

Hydrophilic drugs are one of the most challenges in biopharmaceutical research. Hydrophilic drugs show low bioavailability following oral administration because of their poor intestinal permeation. This review sets out to discuss about anatomy and physiology of the intestinal barrier, drug absorption from intestinal tract, mechanism of intestinal drug permeability, detail information about intestinal permeation enhancers and its mechanism of action, in-vitro methods for studying drug permeability, advantages and applications of intestinal permeation enhancers.

Beeja, Beejabhaga & Beejabhagaavayava are the fundamental factors responsible for the genesis of human being. Ayurvedic Acharyas explained the genetic concept to a greater extent and which simulate with the contemporary concept of genetics mentioned in modern science. Vandhya, Putipraja, Varta and Trina putrika are the diseases manifest due to defect in genes(Beeja, Beejabhaga & Beejabhagaavayava). Phenotypic sex determination begins with genetic sex and which determines phenotypic sex. The nature of gonad present determines the differentiation/regression of the internal ducts (ie, müllerian and wolffian ducts) and ultimately determines the phenotypic sex. Gender identity is determined by the phenotypic appearance of the individual and it is also determined by the brain's prenatal and postnatal development as influenced by the environment.  Any defect in Beeja, Beejabhaga & Beejabhagaavayava causes genetic abnormalities. A diet, behaviours, psychological factors, injuries and iatrogenic factor causes abnormalities in Shukra. Vandhya, klaibya, putipraja, varta, shanda, dwireta etc. are the diseases develop due to shukradushti. It may be  due to Chromosomal problems, hormone imbalance, illness in the mother, disorders of the immune system, abnormalities in the uterus, and environmental and lifestyle factors such as smoking, alcohol and drug use, and exposure to high levels of radiation are often among the  reasons. Keywords- Beeja, Beejabhaga, Beejabhagaavayava, Vandhya, HUMAN GENOME PROJECT

The rhizome of Bergenia ligulata, belonging to the family Saxifragaceae was screened for its antimicrobial activity against Escherichia coli, Staphylococcus aureus, Streptococcus pneumoniae and Salmonella typhii using agar well diffusion method. Methanol extract exhibited larger inhibition zone 21mm against Staphylococcus aureus and Streptococcus pneumoniae as compared to Salmonella typhii and Escherichia coli. Ethanol extract showed larger inhibition zone against Staphylococcus aureus and Salmonella typhii. Acetone extract showed larger inhibition of 24mm zone against Escherichia coli as compared to Staphylococcus aureus, Salmonella typhii and Streptococcus pneumoniae. Water extract showed largest inhibition zone of 25mm against Staphyloccus aureus as compared to Salmonella typhii, Escherichia coli and Streptococcus pneumoniae. The presence of phytochemicals like Saponins, Flavonoids, Phenols, Tannins, Quinones, Carbohydrates, steroids and alkaloids supports its use as medicinal plant for the treatment of various ailments.