Study of Synergistic Anti-inflammatory Action of Murraya Koenigii and Mangifera Indica Leaf Extracts
Mohammad Ashraf*, Deepak Kumar
Basedia, B.K. Dubey
TIT College Of Pharmacy, Bhopal, Madhya
Pradesh, India
ABSTRACT
The objective of the present study was
to assess the anti-inflammatory potential of combined extracts of Murraya koenigii and Mangifera indicausing the carrageenan
induced rat paw edema method. The extraction yield in methanol was found to be
26.8 % for Murraya koenigii and 31.6
% for Mangifera indica. The findings
of preliminary phytochemical analysis suggest the presence of alkaloids,
saponin glycosides, phenolics, terpenoids, and flavonoids in the leaf of the Murraya koenigii while alkaloids and
glycosides were not found to be present in Mangifera
indica. The total phenolic content of the hydroalcoholic extracts of M. koenigii and M.indica were 34.27±1.7 and 43.11±2.1 GAE mg/g, respectively. The
phenolic content was highest in the combined extract (MSE:MIE, 1:2) of all the
three combinations with total phenolics 61.22±4.1GAE mg/g. The extracts were
individually and in combination (1:1, 1:2 & 2:1) subjected to determination
of anti-inflammatory potential by carrageenan induced rat paw edema method
using ibuprofen as the standard drug. Ibuprofen at dose of 10 mg/Kg inhibited
69.23% edema after 4h of administration whereas the maximum edema inhibition
exhibited by the combined extracts was 55.22% (MKE:MIE, 1:2) at the end of 4h.
Keywords:
Murraya
koenigii, Mangifera
indica, carrageenan, Anti-inflammatory,paw edema, Extract