K.S. Srilatha1*, A. Geethalakshami1
1. Department of Pharmaceutics, RR college of Pharmacy Bangalore 560090.
Treatment of hypertension with
conventional dosage forms is not effective as the drugs do not reach the site
of action in appropriate concentration and it is also requiring dosing. Thus,
an effective and safe therapy of hypertension disorder using specific drug
delivery system is a challenging task to the pharmaceutical technologists. Most
commonly used method of modulating the drug release is to include it in a
matrix system, because of their flexibility, hydrophilic polymer matrix system
is widely used in oral controlled drug delivery to obtain a desirable drug
release profile, cost effectiveness and broad regulatory acceptance. In present
study we have prepared matrix tablet formulations using Prazosin as model drug
and Ethyl Cellulose, Two grades of Hydroxy propyl methyl cellulose- HPMC-K4M
&HPMC-K100M as polymers in different ratios. The developed matrix tablets
were evaluated for different physical chemical evaluations like drug content,
hardness, friability, swelling index etc. All the formulations had shown the
results within prescribed limits. The In vitro drug release study
indicates that formulation F7 containing EC, HPMC K100M in 1:2 ratio shown good
release pattern for 14 hours compare to other formulations. The short-term
stability study proven no change in the formulation upon ageing and it
indicates good stability.
Prazosin, Matrix tablets, Ethyl Cellulose and HPMC-K4M & K100M.