Shivaji Vasudeo Shinde1*, Ritesh Suresh Bathe1
1. Department of Pharmaceutics, Sahyadri College of Pharmacy, Methwade, Sangola-413307, Solapur, Maharashtra, India.
Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. Oral controlled release and site specific drug delivery system has been of great interest in pharmaceutical field to achieve improved therapeutic advantage. Gastro retentive drug delivery system is one of such novel approaches to prolong gastric residence time, thereby targeting site specific drug release in the stomach for local or systemic effects. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the gastric emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Floating drug delivery systems are low-density systems that float over the gastric content and remain buoyant in the stomach for a prolonged period of time. They enhance drug bioavailability, reduce drug wastage and provide controlled drug delivery and better patient compliance. The recent developments of FDDS including the physiological and formulation variables affecting gastric retention, approaches to design single -unit and multiple unit floating systems, and their classification and formulation aspects are covered in detail.
Keywords: Controlled release (CR), Gastro retentive, Floating drug delivery.