ABSTRACT

Pavetta corymbosa (Rubiaceae) is a plant traditionally used in sub-Saharan Africa for the treatment of pathologies such as malaria, pain, diabetes, hemorrhages, bacterial infections and typhoid fever. However, there is no scientific information on its analgesic potential, hence the interest of this study which is to evaluate the analgesic potential of the leaves of this plant which would justify its use in traditional medicine. The analgesic effect of the aqueous and hydroethanolic extracts of Pavetta corymbosa at doses of 200 mg / kg of body weight was evaluated by the injection of acetic acid 1% to mice in comparison with paracetamol (reference analgesic) at a dose of 150 mg / kg. The results showed that aqueous and hydroethanolic extracts significantly reduced abdominal contortions in mice (p < 0.05). However, the analgesic effect of both types of extracts is comparable to that of paracetamol. Hence the interest in its use in traditional medicine against certain pathologies.

Keywords: Pavetta corymbosa, analgesic, aqueous extract, hydroethanolic extract.

ABSTRACT

Emulgel is a promising novel formulation for the topical delivery of antifungal drugs. Emulsions and gels synergize to deliver effective treatment solutions. The formulation of this type improves drug solubility, stability, and controlled release, which is effective in the treatment of fungal infections. Emulgels act as both emulsions and gels, thus improving bioavailability through dermal delivery. Such formulation enhancements ensure drug deposition in the target location, diminishing systemic absorption and reducing the eventual side effect profile. It is a distinctive gel-emulsion-based delivery system that combines the benefits of both gels and emulsions, providing double release control. Because of its thixotropic properties, non-greasy texture, easy application and removal, emollient activity, and longer shelf-life, this preparation has proven to be a very useful topical delivery system that also offers superior organoleptic properties. However, specific factors, formulation strategies, characterization parameters, and the consequences of different excipients on both stability and effectiveness in emulgels have been described in this review. This review compiles the advances in antifungal drug-loaded emulgels with an emphasis on recent developments, as well as challenges and opportunities to establish a realistic benchmark for further development in the optimized formulation of emulgels that can attain clinical application.¹

Keywords: Emulgel, Microemulsion, Topical delivery, Antifungal drugs, Sustained release.