Role of Glutathione-S-Transferase gene susceptibility in patient with Bronchial asthma
Chandan Kumar1 , Priyanka Gaur1, Sarika Pandey2, Bhattacharya S*1
1.Department of Physiology King George's Medical University, Lucknow
2.Department of Pulmonary Medicine King George's Medical University, Lucknow
Asthma is one of the most common chronic diseases in the world which can cause considerable morbidity and a significant mortality. Hence it is important to find out the different molecular diagnostic marker which can be use for early detection as well as treatment of patient with bronchial asthma. GST biomarkers is likely become important not only as risk factors in the pathogenesis of asthma but also as determinants of responsiveness to treatment. This review represents the evidence reported the association between gene polymorphism of glutathione-s-transferases (GSTs) GSTP1, GSTM1, GSTT1 gene and bronchial asthma. The data of Indian scenario demonstrate that the Polymorphism of Glutathione-s-transferase gene GSTT1, GSTM1 and GSTP1 is not significantly associated with Bronchial asthma in northern Indian population due to low sample size.
Keywords: Bronchial Asthma; GST; Polymorphism