A Schematic Review on Solid Lipid Nanoparticles Targeting to Brain
G.Y. Srawan kumar1, K. Madhuri*1.
1. Department of Pharmaceutics, Hindu College of Pharmacy, Amaravathi Road, Guntur-522002, (A.P.) India.
Targeting drug to brain is becoming a challenging task for inventors of advanced drug delivery systems. Because the blood brain barrier acts as a barricade for many chemical moieties to cross it for treating CNS disorders. Solid lipid nanoparticles (SLNs) are the effective lipid based colloidal carriers which were introduced as an alternative to the conventional carriers such as micro emulsions, liposomes, microparticles and nanoparticles based on synthetic polymers or natural macromolecules. SLNs were introduced to overcome problems of polymeric nanoparticles by putting forward physiological safe lipids in place of polymers to prepare lipid nanoparticles, a novel formulation technique came into light. An approach undertaken here is to focus on various production methods for preparation of SLNs.
Keywords: Introduction; Blood Brain Barrier; Colloidal Carriers; SLNs; Methods of preparation