Heyam Saad Ali1, Gazala Afreen Khan 1, Babiker M.A.Elhaj2
1.Department of Pharmaceutics &Medical Sciences, Dubai Pharmacy College Dubai, United Arab Emirates
2. Ajman Universities of Science and Technology, Sharjah, United Arab Emirates.
Particle technology in pharmaceutics is a technique to alter physicochemical, micrometrics and biopharmaceutical properties of the poorly soluble drugs, in this manner improving their solubility. Amongst numerous techniques for solubility enhancement, physical modifications of drug products such as reducing the particle size and altering crystal habit are added common methods to increase drug solubility. Other than conventional micronizing techniques, particle technology it now deals with numerous particle and nanoparticle engineering developments as likely methods for improving drug solubility. This review focuses principally on various particle technologies, from conventional size reduction methods to recent novel approaches that can be used for formulating drugs with reduced aqueous solubility.
Keywords: Particle size reduction technologies; Mechanical micronization; Cryogenic spray processes; cyclodextrins; Nanocrystal technology; Freeze-dried liposomes; Polymeric micelles; Freeze-dried liposomes; Phytosomes; Nanodispersions