ABSTRACT

The present work is focused on the development, evaluation and statistical optimization of almotriptan malate transdermal patches. Almotriptan malate is used as anti-migraine drug and reported to have the best-sustained pain free rate and the lowest adverse events rate of all the triptans and thus making interest in the development of new route for the therapeutic administration of the drug, So, the present research work was aimed to develop  matrix type transdermal patches  using polymers HPMC K15M, ERS100 and EC and plasticizers DBP and PEG400 by solvent casting method. This formulation would help to avoid non-compliance of the tablet dosage form The IR spectra of the drug and physical mixtures of drug-polymer confirmed the absence of incompatibility between drug and polymers. The in-vitro drug release studies revealed that patches made of HPMC K15M-ERS 100 with DBP as plasticizer was considered as the best formulation and incorporated in 2² factorial design and evaluated for further studies.  The concentration of HPMC K 15M and ERS 100 are chosen as the independent variables.  Drug content, %moisture absorption  %, moisture loss, and cumulative % drug released at 12h are chosen as dependent variables. The drug release from transdermal patches followed zero order kinetics. Various physicochemical parameters of the patches were investigated. The current research work of transdermal patches of almotriptan malate may provide sustained delivery for prolonged periods in the management of migraine, which can be a good way to bypass the extensive hepatic first-pass metabolism.

Keywords:  migraine, almotriptan malate, transdermal patches, solvent casting, 2² factorial design

ABSTRACT

Proton transfer reaction mass spectrometry (PTR-MS) allows for real time, online determination of absolute concentrations of volatile organic compounds (VOCs) with a high sensitivity and low detection limits (in the parts per trillion ranges). The technique utilizes H3O+ions for proton transfer reactions with many common VOCs while having little to no reaction with any constituents commonly present in it are detected by PTR- TOF .It combines the desirable attributes of high sensitivity and short integration times with good precision and accuracy . Medical applications by means of breath analysis allow the monitoring of metabolic processes in the human body, and examples of food research include investigations of volatile organic compound (VOC) emissions from fruit, coffee and meat. Investigations of VOC emissions from decaying bio-matter and on-line monitoring of the diurnal variations of VOCs in ambient air are typical examples of Environmental applications.

Keywords: PTR-MS, Volatile organic compounds, PTR -TOF.

ABSTRACT

Sexual dysfunction is defined as any discomfort experienced by an individual or a couple during any stage of a normal sexual activity.  According to ICD-10 sexual dysfunction is a condition in which an individual or couple is unable to perform sexual intercourse as both would wish. Atherosclerosis of the arteries supplying genital tissue which elevate sexual function. Typical antipsychotic induce relatively high chances of developing sexual dysfunction in comparison to atypical antipsychotics.

Keywords : Sexual dysfunction, Antipsychotics, Sexual intercource, ICD-10.