ABSTRACT

From the last decade great interest generated on replacing conventional administration of drug by delivery system which would release effective quantities from a protected supply at a controlled rate over a long period of time. An appropriately designated controlled release drug delivery system is the major advance toward solving problems concerning targeting of a drug to a specific organ or a tissue and controlling the rate of a drug delivery to the target site. Matrix system are favoured because of their simplicity, patient compliance etc, than traditional drug delivery(TDS) which have many drawbacks like repeated administration, fluctuation in blood concentration level etc. Developing oral sustained release matrix tablet with constant release rate has always been a challenge to the pharmaceutical technologist. Most of drugs, if not formulated properly, may readily release the drug at a faster rate, and are likely to produce toxic concentration of the drug on oral administration. So that selecting appropriate polymers have become product of choice as an important ingredient for formulating sustained release formulations.

Keywords: Sustained release, Conventional tablet, Controlled release system, Matrix tablet.

ABSTRACT

The cFMS inhibitory activity of 2´-aminoanilide derivatives has been quantitatively analyzed in terms of Dragon descriptors using CP-MLR. The analysis has provided a rational approach for the development of new 2´-aminoanilide   derivatives, the cFMS inhibitors, as potential anti-inflammatory agents. The descriptors identified in CP-MLR analysis have highlighted the role of atomic properties in respective lags of 2D-autocorrelations (MATS7m, MATS5v and GATS2p), path/walk ratio 2-Randic shape index (PW2) and Lovasz-Pelikans’ leading eigenvalue index (LP1) to explain the biological actions of 2´-aminoanilide derivatives as cFMS inhibitors. Certain structural fragment (C-001) and functionality (nCrHR) in molecular structures have also shown prevalence to optimize the cFMS inhibitory activity of titled compounds. Applicability domain analysis revealed that the suggested model matches the high quality parameters with good fitting power and the capability of assessing external data and all of the compounds was within the applicability domain of the proposed model and were evaluated correctly.

Keywords: QSAR, 2´-Aminoanilides; cFMS inhibitors, anti-inflammatory agents, combinatorial protocol in multiple linear regression (CP-MLR).

ABSTRACT

The present work aims to prepare fast dissolving films of Losartan Potassium with purpose of developing rapid onset of action, which is very convenient for administration without using water. Fast dissolving films are meant to be dissolved in saliva and remain in oral cavity until swallowed. The films were prepared by solvent casting method and characterized by UV, DSC studies. The plasticizer concentration was selected on the basis of flexibility, tensile strength and stickiness of the film. In the present study polyethylene glycol was used as plasticizes. Fast dissolving films were evaluated for drug content and the drug loading capacity. The dissolution profile and folding endurance were found to be satisfactory. The disintegration time of formulation F3 film was lowest (30 sec), so they release drug faster than other formulations. A drug-excipients interaction was performed by DSC and FTIR; results were shown that there was no interaction between drug and excipients used. In vitro release mechanism was evaluated by subjecting  the dissolution data to various kinetic models and the drug release was found to best fit the Korsemeyer-peppas model. Hence it is concluded that Losartan Potassium fast dissolving films are successfully developed and evaluated.

Key Words: Fast dissolving films, Losartan Potassium, Solvent casting method, Hypertension

ABSTRACT

Etodolac is a non steroidal anti-inflammatory drug. it is an inhibitor of cycloxygenase which belongs to the pyranocarboxylic acid group. Which is effective in treating fever, pain, and inflammation in the body. which is degraded in stomach .Thus, the purpose of the study is to formulate a dosage form which is coated by coating polymer(s) which passed the acidic medium and exhibit significant effect in intestine. An attempt was made to formulate microspheres with two coating polymers: HPMC & Ethyl Cellulose as well as using of floating properties of polymers will release drug in controlled manner. Thus, these different type of microspheres was characterized in terms of Particles size, buoyancy study, Entrapment efficiency and In-vitro studies.

Keywords: -Etodolac, Coating polymers. etc.

ABSTRACT

A simple, sensitive, accurate and precise simultaneous UV spectrophotometric method has been developed for the estimation of Ciprofloxacin HCL, Doxycycline Hyclate  and Phenazopyridine HCL in tablet dosage form .The absorption maxima of the drugs were found to be 277, 273 and 392 nm for Ciprofloxacin HCL, Doxycycline Hyclate  and Phenazopyridine HCL respectively, in water, using a Shimadzu UV–Visible spectrophotometer (model UV-1800). Ciprofloxacin HCL, Doxycycline Hyclate  and Phenazopyridine HCL in obeyed Beer’s law in the concentration range of 2-10 μg ml-1, 2-10 μg ml-1 and 2-10 μg ml-1 respectively. The correlation coefficient was found to be 0.999, 0.999, and 0.999 for Ciprofloxacin HCL, Doxycycline Hyclate  and Phenazopyridine HCL respectively .The method was validated for various parameters according to ICH guidelines. The low relative standard deviation values indicate good precision and high recovery values indicate accuracy of the proposed method. Assay results were in good agreement with label claim.

Keywords: Ciprofloxacin HCL (CIPRO) , Doxycycline Hyclate(DOXY) and Phenazopyridine HCL(PHENA), UV spectrophotometric method, simultaneous equation method.