A Comparative Study On The Efficacy of Piperacillin/Tazobactam In The Treatment of Pyogenic Infections
Binu Mathew1, Nimmy N John1, H.Doddaya1
1.Department of Pharmacy practice N.E.T pharmacy
college., Raichur, Karnataka 584 101
Antibiotic resistance is a condition where in the antibiotic loses its ability to efficiently control or kill the growth of the bacteria due to which the microorganism continue to multiply and grow in spite of the drug being present in therapeutic levels in the body. Some resistance have no human control over them. How ever, the current scenario of higher levels of antibiotic resistant bacteria are due to the excessive irrational use or abuse of antibiotics. Patients who were prescribed with either piperacillin / tazobactum or a broad spectrum cephalosporin are enrolled in the study. Demographic data, co morbidities and antimicrobial exposures were collected from the patients. culture sensitivity of Piperacillin/tazobactum was conducted in the department of microbiology. Resistance is a worldwide concern, it’s first and foremost problem encountering in antimicrobial therapy. In reality, the extensive use of ? lactam antibiotics in hospitals and communities has created major evolutionary pressures in bacteria to evolve towards resistance. The ? lactamase antibiotics are the largest and currently most widely used antibacterial agents. Therefore, their resistance means a level of antimicrobial activity associated with a high likelihood of therapeutic failure. The present study reveals the effectiveness of piperacillin/tazobactum over the commonly prescribed cephalosporins.
Keywords: Antibiotic Resistance, cephalosporins, piperacillin, tazobactum, hepato biliary, ? lactamase