ABSTRACT

Antibiotic resistance is a condition where in the antibiotic loses its ability to efficiently control or kill the growth of the bacteria due to which the microorganism  continue to multiply  and grow in spite  of the drug being present in therapeutic levels in the body.  Some resistance have no human control over them. How ever, the current scenario of higher levels of antibiotic resistant bacteria are due to the excessive irrational use or abuse of antibiotics.  Patients who were prescribed with either piperacillin / tazobactum or a broad spectrum cephalosporin are enrolled in the study. Demographic data, co morbidities and antimicrobial exposures were collected from the patients. culture sensitivity of  Piperacillin/tazobactum was conducted in the department of microbiology. Resistance is a worldwide concern, it’s first and foremost problem encountering in antimicrobial therapy. In reality, the extensive use of ? lactam antibiotics in hospitals and communities has created major evolutionary pressures in bacteria to evolve towards resistance. The ? lactamase antibiotics are the largest and currently most widely used antibacterial agents. Therefore, their resistance means a level of antimicrobial activity associated with a high likelihood of therapeutic failure. The present study reveals the effectiveness of piperacillin/tazobactum over the commonly prescribed cephalosporins.

Keywords: Antibiotic Resistance, cephalosporins, piperacillin, tazobactum, hepato biliary, ? lactamase

ABSTRACT

Drug therapeutic effectiveness depends upon the drug molecules solubility and the bioavailability of drug molecules. After oral administration of drug to give pharmacological response, solubility is crucial parameter for obtaining desired concentration of drug molecule in systemic circulation. In current scenario about 40% of the newly developed drug molecules is poorly water soluble. With rate of dissolution and pharmacokinetic parameters like, absorption, distribution and excretion of drug molecules depend upon its solubility. Depending upon solubility and permeability, drugs are classified into four basic classes of the biopharmaceutical classification system (BCS) classification. The problem of poor solubility are faced in the Class II and Class IV of the biopharmaceutical classification system which comprises of novel generation of most all category of drugs like NSAIDs like Zaltoprofen,; anti-diabetics Gliclazide; newer calcium channel blockers like Nimodipine,. Till date various methods of ameliorating the solubility has been discovered and utilized successfully to enhance the solubility. This review highlights briefly on information about important approaches of novel solubility enhancement techniques.

Keywords: Solubility enhancement, Cryo-technology, Sono-crstallization

ABSTRACT

Human monkey pox is an emerging viral zoonotic disease. This is caused by monkey pox virus. Monkey pox has a clinical presentation like flulike symptoms characteristic rash fever, malaise, back pain, and headache. Primarily monkey transmission to human is believed to occur through direct contact with infected animals (or) possibly by ingestion of inadequately cooked flesh. The review article mainly discuss about orthopox virus genes have been  shown to suppress anti-viral cell defenses, exploit host cell machinery and delay infection induced cell death. And control there are no licensed therapies to treat human monkey pox viral infection, however the small pox vaccine can protect against the disease. The management of monkey pox is mainly used this medications like Small Pox Vaccine, Cidofovir, Brincidofovir, Tecovirimat, Vaccinia Immune Globulin (VIG). Discontinuation of vaccination has given rise to increasing susceptibility to monkey pox viral infection. This lead to a fear of bioterrorism. Effective prevention limiting contact with infected patients (or) animal. Limiting the respiratory exposure to infected patients. Mortality and Morbidity rate of this virus is very rare conditions. This virus mainly prone to neonatal & pediatric patients, the hospital stay is minimum of 4 weeks.

Keywords: Benign epidermal Monkey Pox (BEMP), Democratic Republic of the Congo (DRC), Monkey Pox Virus (MPV), Polymerase Chain Reaction (PCR), Immunoglobulin M (IgM), Center for Disease Control and Prevention (CDC), Fold Change Ratios (FCR), Ingenuity Pathway Analysis (IPA), Vaccinia Immune Globulin (VIG).

ABSTRACT

Chia seeds (obtained from plant Salvia hispanica; Lamiaceae family.) are referred to be the superfoods in the health community. These seeds are rich in protein, dietary fibers, omega 3 fatty acid, flavonoids, polyphenolic compound, Vitamin C&K. Minerals like potassium, manganese, copper, calcium, magnesium also contribute toward its nutritional profiling. It’s oil is rich in several bioactive compounds namely quercetin, kaempferol, myricetin, cholorgenic acid & 3,4-dihydroxyphenyl ethanol- elenolic acid di-aldehyde (DHPEA-EDA) .Study showed that chia seeds exhibited anti-inflammatory, anti-cancer, anti-hyperglycemic, anti-oxidant properties.

Keywords: Chia seeds, Salvia hispanica, Super food, Omega 3-fatty acid, polyphenolic compound, antioxidant.