ABSTRACT

The results of this study, according to the stated her goals are to show identification counter the type of life and vegetation demodulator within the appropriate concentrations and the presence of a large and effective overlap when mixing anti-life with vegetable extract, as this study showed that the mixing of the anti-life process (Ceftriaxone?), with vegetable alcoholic extract and concentration (8 %), the highest percentage inhibition of (16 mm), while the inhibition "damping-scale" space for an anti-life with an aqueous extract of green apple reached (11 mm), which refers to how effectively the synergistic mixture germ (Streptococcus viridians that causes tooth decay). Which leads us to think about using natural treatments rather than medical drugs and treatments chemical harmful health through the side effects harmful to their users, and costly economically income individuals and governments. So we recommend people with plenty of eating apples because it would interest at large to prevent disease and also said the wise old (one apple in the morning keeps the doctor away). That's what has been proven later through research conducted by a number of specialists in this area, where they are to complete the function of apples through the chemical components of effective clinically in the treatment of many diseases, particularly disease tooth decay, which is caused by bacteria (Streptococcus viridians) that what has been proven through experiences we had in this research and what has been proven in previous research to our present.

Keywords: Streptococcus viridans, Teeth caries, Ceftriaxone?, amoxicillin, green apples.

ABSTRACT

Sepsis is a life-threatening condition that occurs when the immune system responds to infection. Studies have shown proven results that statins control the inflammatory response associated with sepsis, which may help to minimize the disease's development and lower mortality rates. A 9-month retrospective and prospective observational study was carried out. Two groups were classified as statins and non-statins. 205 patients were included in this study, out of which 71 patients (35%) were taking a statin, while 134 patients (65%) were in non-statin group. Out of 71 patients belonging to statin group, 25 patients (35%) were prescribed with Atorvastatin, 21 patients (30%) were prescribed with a combination of Atorvastatin and Aspirin, and 4 patients (6%) were prescribed with Rosuvastatin. The incidence of multiple organ dysfunction syndrome was found to be in 28 patients (21%) of the non-statin group and 12 (17%) in the statin group and the mean multiple organ dysfunction syndrome rate among the non-statin group was 1.98 compared to 1.83 for statin group. The incidence of mortality rate among the non-statin group was found to be 72 patients (54%) compared to the statin group 29 patients (41%). The mean sequential organ failure assessment score for the non-statin group was 7.78 compared to 7.03 for the statin group and was statistically significant. Though the mortality rate was statistically insignificant in the statin group, the overall improvement in the statin group was comparatively better than in the non-statin group.

Keywords: Sepsis, Statins, Mortality Rate, Organ Dysfunction Scores.

ABSTRACT

The aim of the present work was to develop and validate a simple and efficient method for the analysis of Aprepitant in pharmaceutical dosage forms by reverse phase high-pressure liquid chromatography. A stainless steel column 75 mm long, 4.6 mm internal diameter filled with octasilyl silica chemically bonded with synthetic hybrid silica gel particles of 3.5 mm diameter was used for elution. The retention time of Aprepitant was 4.05 min. The method showed a good linearity in the concentration range of 0.02478 – 0.07434 mg/mL with a correlation coefficient of 0.9999. The validation characteristics included specificity, linearity, limit of detection, limit of quantification, precision, robustness and stability. Validation acceptance criteria were met in all cases. The method could be successfully used for the analysis of Aprepitant in pharmaceutical dosage forms.

Keywords: Aprepitant, Accuracy, Precision, Linearity, Mobile Phase and Validation