ABSTRACT

Parkinson’s disease is the second most chronic neurodegenerative disorder, That impair motor skills, and cognitive performance. Most of the conventional therapies only focus on suppression of symptoms in the disease. But the emerging novel phytochemical compounds have significant effect on its Neuropsychopharmacological mechanisms. These compounds shows neuro-protective action and also decrease the oxidative stress, neuro-inflammatory pathogenesis of Parkinson’s disease. Most of the adverse reactions of conventional treatment are reduced by   novel compounds.

Keywords:  Parkinson’s disease, neuroprotective, neuroinflammatory, oxidative stress

ABSTRACT

It was in late 2019 when the world got alarming news of the fatal virus that took birth in the seafood market of China (Wuhan) and a few months later pandemic was announced by WHO. This virus was named novel coronavirus (SARS-CoV 2) which has its clinical features similar to “pneumonia” including human to human contact. According to its genomic structure, it belongs to betacoronavirus having a crown-like presence and is a positive-sense RNA virus. Meanwhile, as per the reports, the treatment options contain the use of some antiviral drugs like Lopinavir, Ritonavir, Remdesivir, including Ayurvedic System of Medicine. In this pandemic situation, the pharmacists play a vital role in providing medical services to the patients. All over the world, many pharmaceutical firms have collaborated to develop the vaccine to combat COVID-19 as soon as possible and will soon make the world corona free. This coordination globally, has helped and fasten the development of vaccine with several vaccine candidates initiating human trials. The mental health of people has been affected to a great extent. This review explains the structure, manifestations and how Covid-19 led to the global emergency. The fatal effect of virus on three countries- Italy, USA and India are also described.

Keywords: Coronavirus, Pandemic, Remdesivir, Wuhan city, Pneumonia