ABSTRACT

The historians have recorded many applications of aloe species both in the medical field as well as in cosmetics. It is used to heal burns, to prevent blisters for the treatment of wounds and in various kinds of damaged skin. Burns are serious traumas related to skin damage, causing extreme pain and natural drugs such as Aloe vera is beneficial in formulations for wound healing. The aim of this work is to develop and evaluate polymeric films containing Aloe Vera crude extracts to smoothen and treat minor wounds caused by burns. Polymeric films containing different quantities of HPMC and polyvinyl alcohol (PVA) were characterized for their mechanical properties. The polymeric films, which were formulated, were found to be thin, flexible, resistant, and suitable for application on damaged skin, such as in burns & wounds. The formulated gel was evaluated for evaluations parameters were thickness, tensile strength and water vapour permeability. general appearance, homogeneity, pH, spreadability test, washed test and skin irritation test. Film

Keywords: Aloe Vera, Gel and Film. 

ABSTRACT

Herein we report an exploratory study based on the cytotoxicity and antiproliferative activity of four previously synthesized coumarins derivatives (compounds 1a-d). The cytotoxic effect of the compounds was assessed on mononuclear cells, which were obtained from blood samples of healthy donors and measured by XTT method. The antiproliferative activity experiments were developed using HeLa, CaSKi and SiHa cervical cancer cell lines, and was evaluated by the MTT assay. In every single experiment, Cisplatin as internal control was employed. The cytotoxic assessment revealed that the four compounds did not significantly affect the viability on normal cells, whereas the antiproliferative activity on cancer cells was variable, according to the substituent located at position 3 of the coumarin core. It is worth mentioning that compound 1c, compared with the other products, presented a remarkable effect against CaSKi cell line, likewise 1d but in HeLa cells. These findings suggest that there is a relationship between biological activity and the alkoxycarbonyl chain since this is the only structural difference among the four tested compounds. The results lead to conclude that butyl group which is the substituent in compound 1d, was the key element in the antiproliferative effect presented by the molecule against SiHa, CaSKi and HeLa cell lines.

Keywords: Coumarins, Tumor cells, Mononuclear cells, Cis-Platin, Cytotoxicity, MTT.

ABSTRACT

In this paper we present a case of a 9 year old male patient with a rare form of extra pulmonary tuberculosis-tuberculous meningitis. Meningitis is an inflammation of the meningeal layers of the brain and spinal cord. Different types of meningitis have been determined, each with its own causes, risk factors and side effects. Here are the five most common types of meningitis, they are Viral Meningitis, Bacterial Meningitis, Parasitic Meningitis, Fungal Meningitis, Chronic Meningitis. TBM is a rare form of extra pulmonary tuberculosis.

Keywords: Extra pulmonary tuberculosis, tuberculous meningitis.