American Journal Of Pharmacy And Health Research

ISSN NO.: 2321-3647
July 2018 Issue 7

Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy

Akila RM1*, Sneha Anna Saju1

Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna Institute of Paramedical Sciences, Coimbatore, India.


Nanoparticles are designed to improve the pharmacological and therapeutic properties of conventional drugs. In the present research work, almotriptan malate was formulated as nanoparticle drug delivery system for the effective management of migraine by ion-gelation technique. Shape and size of the nanoparticles were evaluated by TEM images. FTIR and  DSC studies confirmed that there were no interactions between the drug and the other ingredients. XRD study was carried out to confirm the crystalline or amorphous nature of the nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug loading capacity was found to be 15 to 16% The in-vitro release studies concluded that the release was sustained after an initial burst. The in vitro mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The kinetic study revealed that the almotriptan malate nanoparticles followed the first order kinetics.

Keywords: biodegradable chitosan, nanoparticles, almotriptan malate,  mucoadhesion



Formulation and Optimization of In-Situ Buffered Formulation Containing Indomethacin In Combination With Pantoprazole

Preeti Khulbe*: Birendra Srivastava Pankaj sharma

*School of pharmaceutical sciences, Jaipur National University, Jaipur (Rajasthan)


In-Situ buffer formulation contain agents which immediately buffer the internal environment of the body and increases the stability of acid labile drugs inside the body. Here this approach is used for making combination capsule formulation to reduce the side effects of Nonsteroidal anti-inflammatory drugs. Pantoprazole is an acid labile drug which is very useful for the prevention and treatment of NSAID related gastric ulcer, so to reduce its side effects this approach was used. In this Indomethacin is used as Nonsteroidal anti-inflammatory drugs. For this purpose, macroenvironment buffering method was used. Based on their acid neutralizing capacity the best buffering combination was selected. In this method immediate release excipients or superdisintegarnts (SSG & CCS) whereas rate retarding polymers (Guar gum, Xanthan gum & ethyl cellulose) were added in the formula.  Ex vivo permeation study was performed by using Non-everted intestinal sac method in selected optimized batch. For optimization full factorial 23 design was used along with mathematical models. Prepared optimized formulation was compared with marketed formulation. Final pH from optimized formulation was found to be 5 to 6. The prepared optimized capsule is having 98.86% immediate release of pantoprazole sodium sesquihydrate upto 30 min and 99.84% sustain release of indomethacin upto 12 hrs. The prepared formulation showed immediate release of stable pantoprazole sodium sesquihydrate (due to the presence of in-situ buffering agents inside the capsule) along with the sustained release Indomethacin with very less adverse effects.

Keywords: Stable pantoprazole sodium sesquihydrate, sustained release, macroenvironment, Ex vivo permeation.


Design and Evaluation of Doxofylline Immediate Release Tablets

Bharathi Agirela*, Nandini.Akula, Nikitha.Ponnam, Chandra Sekhar Naik.D

Department of pharmaceutics, KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, India


Doxofylline a bronchodilator and anti-tussive is used for chronic obstructive pulmonary disease (COPD) and asthma that acts as phosphor diesterase inhibitor with minimum cardiovascular side effects due to low affinity foradenosine receptors (both A1 and A2) unlike theophylline and other xanthine derivatives. Doxofylline is water soluble and comes under biopharmaceutical classification class III with high solubility and low permeability. In this study an attempt has been made in development and to evaluate the formulation of Doxofylline tablets of 400mg and these compressed tablets were tested for friability, thickness, disintegration time, hardness, weight variation and assay. The formulation trial F4 was optimized considering the drug release profile and the disintegration time of tablets as they were very close to the reference product values. From this study, it may be concluded that for Doxofylline tablets, F4 stands as a successful formulation and can be manufactured with reproducible characteristics from batch to batch to match the release profile with the reference product. The in-vitro release of Doxofylline tablets was studied in 900 ml of distilled water as dissolution medium using an I.P dissolution paddle assembly at 100rpm and 37±2°C for 45min.

Keywords: Doxofylline tablets, Micro crystalline cellulose, HPLC, Antiasthmatic


A Case Report on Thiazide-type Diuretic Induced Fixed Drug Eruption

Rahul Rawat, Yogesh Joshi*, Ankit Sharma

Department of Pharmaceutical Science, Shri Guru Ram Rai Institute of Technology & Science, SGRR University, Dehradun-248001, Uttarakhand (India)


Fixed drug eruption (FDE) is one of the most common cutaneous adverse drug reactions in Indian patients. Chlorthalidone (CTD), a thiazide-type diuretic that inhibits distal convoluted tubule sodium and chloride resorption, is a commonly used oral antihypertensive. We are presenting a case of chlorthalidone induced FDE where a 75 year old hypertensive male admitted in hospital with complains of rashes associated with burning sensation on trunk, back and left arm after the administration of tablet chlorthalidone. FDE is believed to be a lymphocyte CD8-mediated reaction, wherein the offending drug may induce local reactivation of memory T cell lymphocytes localized in epidermal and dermal tissues and targeted initially by the viral infection. The initial treatment of FDE is discontinuation of the causative agent.

Keywords: Fixed drug eruption, Chlorthalidone, Cutaneous adverse drug reactions


Harmful Effects of Alcohol On Essential Physiological Organs

Shahnawaz Ahmad Teli, Yogesh Joshi*

Department of Pharmaceutical Science, Shri Guru Ram Rai Institute of Technology & Science, Dehradun-248001, Uttarakhand (India)


Alcohol abuse is one of major and increasingly attributable risk factor for mortality and morbidity worldwide. The underlying purpose of this review is to promote awareness and significance in relation to the effects of alcohol on various body systems especially on cardiovascular system, liver, adipose tissue, skeletal muscle, brain, water and electrolyte metabolism and endocrine system. Alcohol when used above the normal range can results in harmful consequences on different biological organs. Average volumes consumed and patterns and frequency of drinking are three dimensions of alcohol consumption that need to be considered in efforts to reduce the burden of alcohol-related harmful effects. To reduce such harmful effects, national policies need to be developed to keep track of alcohol consumption and its consequences, and to raise awareness amongst the public. It is up to both public and concerned governments to encourage debate and formulate effective public health oriented policies and measures in order to minimize the harm caused by alcohol.

Keywords: Alcohol, consumption, harmful effects, awareness


Pharmacological account of Hibiscus Sabdariffa Linn.

Sudhir S. Mulay*
MES College of Pharmacy, Ram Nagar, Mehkar (443301) Tq. Mehkar, Dist. Buldhana, Maharashtra, India


Hibiscus sabdariffa Linn. is an annual herbaceous shrub, cultivated for its flowers although leaves and seeds have also been used in traditional medicine. The plant is reported to contain proteins, fats, carbohydrates, flavonoids, acids, minerals and vitamins. The plant has been reported to have antihypertensive, hepatoprotective, antihyperlipidemic, anticancer and antioxidant properties. The present paper is an overview on its pharmacological properties reported in the literature.

Keyword: Hibiscus sadariffa, Antihypertensive, Anticancer, Antioxidant, Flavonoids etc.