Design and Characterization of Biodegradable Chitosan Nanoparticles Loaded With Almotriptan Malate For Migraine Therapy
Sneha Anna Saju1
Department of Pharmaceutics, College of Pharmacy, Sri Ramakrishna
Institute of Paramedical Sciences, Coimbatore, India.
Nanoparticles are designed to improve the
pharmacological and therapeutic properties of conventional drugs. In the
present research work, almotriptan malate was formulated as nanoparticle drug
delivery system for the effective management of migraine by ion-gelation
technique. Shape and size of the nanoparticles were evaluated by TEM images.
FTIR and DSC studies confirmed that
there were no interactions between the drug and the other ingredients. XRD
study was carried out to confirm the crystalline or amorphous nature of the
nanoparticles. The entrapment efficiency of was found to be 74 to 82% and drug
loading capacity was found to be 15 to 16% The in-vitro release studies
concluded that the release was sustained after an initial burst. The in vitro
mucoadhesion study using goat nasal mucosa was found to be 54% and 69%. The
kinetic study revealed that the almotriptan malate nanoparticles followed the
first order kinetics.
biodegradable chitosan, nanoparticles, almotriptan malate, mucoadhesion