AJPHR

American Journal Of Pharmacy And Health Research

ISSN NO.: 2321-3647
DOI: 10.21276/ajphr
October 2017 Issue 10
1

Bioinformatics Study on Sequence Characteristics of ?-D-xylosidase in Glycyrrhiza uralensis Fisch

Li Gun1*, Tian Han1, Ren Yumiao1, Du Ning1

1.Department of Biomedical Engineering, School of Electronics and Information Engineering, Xi'an Technological University, Xi'an, Shaanxi Province, China

ABSTRACT

Glycyrrhiza uralensis Fisch is a kind of commonly used herb in traditional Chinese medicine. Effective ingredients in Glycyrrhiza uralensis Fisch has anti-inflammatory and anti-virus effect. In this paper, the main physical characteristics of ?-D-xylosidase from Glycyrrhiza uralensis Fisch are studied from the perspective of bioinformatics. The composition isoelectric point and hydrophobicity etc, of the polypeptide are studied by bioinformatics tools. The results show that the molecular weight of ?-D-xylosidase in Glycyrrhiza uralensis Fisch is 31136.85, the theoretical isoelectric point is 9.56, the instability index is 29.87, the polypeptide does not exist in the transmembrane region, and there are three helical structures in the secondary structure. Finally, this paper summarizes the status and function of Glycyrrhiza uralensis Fisch in the development of traditional Chinese medicine.

Keywords: traditional Chinese medicine; ?-D-xylosidase; Glycyrrhiza uralensis Fisch, Bioinformatics analysis

2

Medicinal Plants – Folk Remedies For Different Skin Problems Used by the MIZO Tribal’S in Mizoram, N.E India.

Zorinpuii Khiangte and *H. Lalramnghinglova

Department of Environmental Science, Mizoram University, Aizawl, Mizoram, India, 796004

ABSTRACT

The present paper deals with different medicinal plants used by the Mizo people exclusively for treating skin problems like boils, sores, dandruff, measles, allergies, burns, carbuncles, scabies, insect bites, eczema, keloids etc. 41 informants were interviewed  in which the use of 105 different plant species were reported.

Keywords: Mizo, informants, carbuncles, medicinal plants, allergies

3

Documentation of Ethno-medicinal Plants used in the treatment of Malaria, Fever and Headache by the Garo Community of West Garo Hills District, Meghalaya.

Naldarine M. Marak1*, Lalnundanga1

1.Department of Forestry, Mizoram University Aizawl, Mizoram-796004, India

ABSTRACT

The Garo hills districts in Meghalaya persistently contributed most on malarial attributable deaths. The research on documentation of ethnomedicinal uses for the treatment of malaria, fever and headache was conducted in West Garo hills district of Meghalaya during the year 2014-2016. Sources revealed that the West Garo hills district is co-endemic for Plasmodium falciparum and Plasmodium vivax, but Plasmodium falciparum was the predominant infection (> 82%). The study has documented 20 medicinal plant species belonging to 16 families. The study based on the plant parts used reveals that roots (40%) were most commonly used in the treatment, followed by leaves and barks (35%), whole plant (10%) and seeds having (5%). In the study trees (50%) were recorded to have highly used potential followed by herbs (30%), shrubs (15%) and climbing shrubs (5%).

Keywords: Ethnomedicine; Malevolent spirits; Oja: West Garo Hills; Meghalaya.

4

Prescription Pattern Analysis of Antibiotics Concerning General Medicine Department In A Tertiary Care Hospital: A Prospective Study

Shaik Kareemulla*1, Dr. Pankaj Kumar Sharma2, Dr. Khaja Pasha3

*1 PhD Research Scholar, Jaipur National University (JNU), Rajasthan

2 Professor & Senior Assistant Director (Pharmacy), Jaipur National University (JNU), Rajasthan

3 Professor, Dept. of Pharmaceutical Analysis, Jawahalal Nehru Technological University (JNTU), Hyderabad

ABSTRACT

Antibiotics are the most commonly prescribed drugs in hospitals. In developed countries, around 30% of the hospitalized patients are treated with antibiotics. Rational uses of drugs have attained more significance in present days in terms of medical, socio economical and legal aspects [1]. Pharmacists play a vital role in promoting the rational use of medicines. Medicines (drugs) cannot be used rationally unless all health care professionals involved in the pharmaceutical supply chain has access to know the complete information therapeutic indications of the drugs This study was carried out to collect patient’s relevant demographic information which includes Age, Sex, Occupation, Date of admission, Date of discharge, History of present illness, past medical history, Diagnosis and prescription drugs [2]. 1) The aim of the research is to study and to determine the prescribing patterns of antibiotics and use of antibiotic (Rational / Irrational) in a tertiary care hospital along with its beneficial and adverse outcomes. 2) Intervene strategies from pharmacist perspective to promote rational use of antibiotics to improve therapeutic outcomes in patients thereby improving quality of life (QOL) of patients [3]. The study was carried at Shadan Institute of Medical Sciences, Shadan Hospital, Hyderabad. Antibiotics are prescribed based on symptoms and laboratory investigations. Antibiotics are indicated for the treatment of bacteriologically proven infections and non-bacteriologically proven infections. It is a single centered, prospective observational study. Subjects of both genders who indicated with antibiotic therapy are taken into consideration and patients who had co morbid pathological conditions also included. Pediatrics, pregnant women and surgical cases were excluded from the study [4].175 patients were collected; 75 were male and 100 were female. Total numbers of antibiotics prescribed are 260. Median duration of hospitalization was 5 days. The most common prescribed antibiotics were Ceftriaxone, Ciprofloxacin, Azithromycin, Amoxicillin+Clavulanic acid, Amikacin & Doxycycline. On assessing the results of study, it was found that prescribed 260 antibiotics accounted for 100%, ceftriaxone indicated was 35% followed by ciprofloxacin was 10 % and azithromycin was 6%. Irrational prescriptions becoming a serious problem in the General medicine department. For the achievement of Rational use of antibiotic to treat infections caused by microorganisms, selection the appropriate antibiotic partly depends on symptoms suffered by the patients. Awareness programs should be launched and seminars should be conducted so as to minimize problems which are common at ward level [5]. News Letters and Drug bulletins about the rational use of antibiotics should be released periodically. Cost effective prescription should be encouraged. Formulation of a policy for hospital antibiotic use and educational programs especially for junior doctors also required.

Keywords: Antibiotics, Drug utilization, General Medicine ward, Rational prescription, Quality of life, Cost effective prescription.