ABSTRACT

Tuberculosis is a bacterial infectious disease caused by Mycobacterium tuberculosis. It is highly infectious and opportunistic disease. The synthetic drugs for anti-tuberculosis effect have been prescribed for symptomatic control of disease but produce much adverse effect. Naturally obtaining medicinal plants are incomparable resources of Siddha. From thousands of years, medicinal plants provide a great hope to curing diseases. This review spotlights the effort on anti-tubercular plants, which are various source of literature. This paper provides the plant description, chemical constituents, evidence based pharmacological activity. This will motivate and provide a way for further researches on medicinal plants, possess potent anti- tuberculosis activity.

Keywords: Tuberculosis, Anti-tubercular activity, Medicinal plants, Siddha.

ABSTRACT

Liquisolid strategy is otherwise called powder solution technology. It is the system which manages the solubility upgrade of inadequately solvent medications. As nowadays there are numerous medications in the market with poor solvency which prompts poor disintegration and bioavailability, so dissolvability is getting to be rate constraining component in the advancement of new medications. To defeat this issue there are numerous systems yet liquisolid strategy is most encouraging procedure which is talked about in this article. Liquisolid is for the most part made out of medication, non volatile solvent, carrier material, coating material, and disintegrant. In liquisolid strategy carrier and coating material which ought to be in the proportion of 20:1 is blended into the non volatile solvent and after that disintegrant is included and last material is packed into tablets. Henceforth, the liquisolid innovation permits the change of fluid frameworks into strong medication conveyance frameworks. Both quick and managed arrival of medication can likewise be accomplished with the assistance of liquisolid procedure. For sustained release of medication hydrophilic polymer like Hydroxy Propyl Methyl Cellulose can be the best choice. The motivation behind this article is to depict about the liquisolid strategy like basics, classification, preformulation examines, characterization, pre compression contemplates, detailing of tablet, post compression thinks about, points of interest, drawbacks, applications.

Keywords: Liquisolid, bioavailability, dissolution, sustained release.

ABSTRACT

Tuberculosis is one among the serious public health challenge worldwide. Among broad range of drugs that are known to induce liver damage, hepatotoxic side effects are serious challenges in patients receiving Anti-TB medications.  First line agents that are used for treating this condition induce various adverse effects including liver injury, skin reactions, and gastrointestinal reactions. However in addition to individual risk factors like age, gender and  hypo albunemia, use of anti tubercular drugs in combination enhances the degree of toxicity as each drug possess varying degree of liver toxicity. Drug induced liver injury (DILI) is the most common and serious adverse reaction caused due to the use of ATT regimen that needs vigilant monitoring in preventing fatal complications. Here we present a case of hepato toxicity induced by use of ATT (Rifampicin 450 mg, Isoniazid 75 mg, Pyrazinamide 400 mg and Ethambutol 275 mg OD) for a period of one month later on which she experienced drug hypersensitivity reactions and altered liver function tests. The suspected ADR was probable ADR (Naranjo’s scale). Offending drug regimen was stopped and second line agents (SLE regimen) along with supportive care were given. Hence it is often essential that clinicians regularly evaluate patients for these conditions to prevent their emergence and progression.

Keywords: ATT (anti tubercular therapy), DILI (drug induced liver injury), Hepato toxicity, Tuberculosis, SLE (streptomycin, Levofloxacin, Ethambutol)

ABSTRACT

In the present study, formulation of mouth dissolving film containing antihistaminic drug Desloratadine was designed to achieve immediate release of drug from the dosage form, to increase therapeutic efficacy and to improve patient compliance in case of allergy. The combination of drug with suitable polymers such as HPMC E-5 and HPMC E-15 helps in providing quick release of the drug. Mouth dissolving film was prepared by solvent casting method using PEG 400 as plasticizer. A 3² full factorial design was applied to an optimized the effect of independent variables like HPMC E-5 and HPMC E-15 on dependent variables like disintegration time, thickness and folding endurance of the film. The responses were analyzed using design of expert software and it was found that the concentration of HPMC E-5 and HPMC E-15 significantly affects on dependent parameters. The prepared optimized formulation showed minimum disintegration time (10s) and highest dissolution rate (99.02 ± 0.284 %). The two check point formulations were prepared as suggested by the software. All the predicted values of responses were found to be close to the observed values. Stability study shows that there was no significant change in physical appearance, disintegration time, thickness, drug content and In vitro drug release of the formulation. Mouth dissolving film is an innovative concept for quick release of the drug. Thus, allergy can be quickly treated by this formulation.

Keywords: Mouth Dissolving film, Desloratadine, HPMC E-5, HPMC E-15, Test masking